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KMID : 1140420230320030279
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Journal of Obesity & Metabolic Syndrome
2023 Volume.32 No. 3 p.279 ~ p.283
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Muscle Mass Adjusted for Body Weight Is Associated with Significant Liver Fibrosis in Young Adults with Nonalcoholic Fatty Liver Disease: A Cross-Sectional Study from a Korean Military Hospital
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Lee Jae-Jun
Na Seong-Joo
Na Jin-Oh
Lee Seong-Woo
Kim Myoung-Jung
Han Chang-In
Bae Si-Hyun
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Abstract
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Background: Sarcopenia has been associated with nonalcoholic fatty liver disease (NAFLD). This study aimed to investigate the correlation between liver fibrosis and muscle mass in young adults with NAFLD.
Methods: We conducted a retrospective review of 88 Korean soldiers <35 years of age who underwent bioelectrical
impedance analysis and liver stiffness measurements. A FibroScan-aspartate aminotransferase score >0.35 was used to determine the presence of liver fibrosis.
Results: Among the 88 patients, 38 were classified as having significant fibrosis. In the univariate analysis, muscle mass percentage (MMP), muscle-to-fat ratio (MFR), waist-to-hip ratio (WHR), body mass index, impaired fasting glucose or diabetes mellitus, and alanine transaminase (ALT) level were all significantly associated with fibrosis (P<0.001). After adjusting for ALT level, height, and age, MMP and WHR were associated with fibrosis.
Conclusion: In young adults, MMP and MFR were significantly associated with hepatic fibrosis.
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KEYWORD
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Non-alcoholic fatty liver disease, Sarcopenia, Liver fibrosis, Muscle mass, Young adult
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